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Synthesis and Analysis of Potential DNA Intercalators Containing Quinoline–Glucose Hybrids
Author(s) -
Li Wei,
Zhang ZhongWei,
Wang ShiXi,
Ren SuMei,
Jiang Tao
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00831.x
Subject(s) - quinoline , triethylene glycol , chemistry , dna , intercalation (chemistry) , fluorescence , biochemistry , combinatorial chemistry , stereochemistry , organic chemistry , physics , quantum mechanics
A new series of potential DNA bisintercalators have been designed by linking 8‐hydroxy‐quinoline to the 6‐CH 2 OH group of glucose and connecting the 1‐OH group of glucose with various linkers, such as quinol, glycol, and triethylene glycol. These new compounds were well‐synthesized and fully characterized. Preliminary binding assays of these compounds to calf thymus DNA (CT‐DNA) were conducted using UV‐absorption and fluorescence spectroscopy analysis. The primary antitumor activity of these compounds was also performed.