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Synthesis and Biological Evaluation of Mercapto Triazolo‐Benzothiadiazine Linked Aminobenzothiazoles as Potential Anticancer Agents
Author(s) -
Kamal Ahmed,
Khan Mohammed Naseer A.,
Srikanth Yellamelli V. V.,
Rajesh Shetti V. C. R. N. C.
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00815.x
Subject(s) - benzothiadiazine , benzothiazole , chemistry , pharmacophore , stereochemistry , combinatorial chemistry , cell culture , erlotinib , biochemistry , medicinal chemistry , biology , receptor , epidermal growth factor receptor , genetics
The synthesis of a series of 10‐substituted 5,5‐dioxo‐5,10‐dihydro[1,2,4]triazolo[4,3‐ b ][1,2,4]benzothiadiazine coupled with sulfanylacetamido benzothiazole pharmacophores ( 5a – g ) is described. All the synthesized compounds have been evaluated for their anticancer activity. Most of the compounds showed significant growth inhibitory activity against selected human tumor cell lines. Interestinlgy, one of the synthesized compounds 5d, exhibited GI 50 values of 1.4 and 2.1 μ m against RPMI‐8226 (leukemia) and HOP‐62 (lungs) cell lines, respectively.