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Convenient and Efficient Preparations of Azodye‐Labeled Peptides
Author(s) -
Katritzky Alan R.,
Chen QiYin,
Tala Srinivasa R.
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00813.x
Subject(s) - tripeptide , chemistry , peptide , chirality (physics) , stereochemistry , combinatorial chemistry , biochemistry , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
N ‐(4‐Arylazobenzoyl)‐1 H ‐benzotriazoles 15a , 15b react with dipeptides 12a – d , ( 12d + 12d′ ) and tripeptides 14a , 14b to give azodye labeled‐dipeptides ( 16a – e ), ( 16d + 16d′ ), ( 16e + 16e′ ) and ‐tripeptides 16f , 16g in high yields (73–93%) with retention of chirality.