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3‐(3‐Ethylphenyl)‐2‐substituted hydrazino‐3 H ‐quinazolin‐4‐one Derivatives: New Class of Analgesic and Anti‐Inflammatory Agents
Author(s) -
Alagarsamy V.,
Raja Solomon V.,
Sheorey R. V.,
Jayakumar R.
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00794.x
Subject(s) - diclofenac sodium , chemistry , analgesic , anti inflammatory , aspirin , stereochemistry , diclofenac , medicinal chemistry , pharmacology , biochemistry , medicine , chromatography
A new series of 3‐(3‐ethylphenyl)‐2‐substituted hydrazino‐3 H ‐quinazolin‐4‐ones were synthesized by reacting the amino group of 2‐hydrazino‐3‐(3‐ethylphenyl)‐3 H ‐quinazolin‐4‐one with a variety of aldehydes and ketones. The title compounds were investigated for analgesic, anti‐inflammatory and ulcerogenic index behavior. The compound 2‐(N′‐3‐pentylidene‐hydrazino)‐3‐(3‐ethylphenyl)‐3H‐quinazolin‐4‐one ( AS2 ) emerged as the most active compound in exhibiting analgesic activity and the compound 2‐(N′‐2‐pentylidene‐hydrazino)‐3‐(3‐ethylphenyl)‐3 H ‐quinazolin‐4‐one ( AS3 ) emerged as the most active compound in exhibiting anti‐inflammatory activity; and these compounds are moderately potent when compared with the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared with aspirin.