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Dye Labelling of Nucleosides
Author(s) -
Katritzky Alan R.,
Khelashvili Levan,
Kovacs Judit,
Shanab Karem
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00792.x
Subject(s) - labelling , chemistry , conjugate , combinatorial chemistry , biochemistry , mathematics , mathematical analysis
Dye‐labelled nucleosides were obtained in 30–79% (average 45%) yields by treating N ‐(4‐arylazobenzoyl)‐1 H ‐benzotriazoles 3a–b with appropriate nucleosides. Similarly, 3a–b afforded dye‐labelled threoninol conjugates in 55–89% (average 67%) yields. All novel products were characterized by NMR and elemental analysis.