Premium
QSAR Study of 2‐(1‐Propylpiperidin‐4‐yl)‐1H‐Benzimidazole‐4‐Carboxamide as PARP Inhibitors for Treatment of Cancer
Author(s) -
Riahi Siavash,
Pourbasheer Eslam,
Dinarvand Rassoul,
Ganjali Mohammad Reza,
Norouzi Parviz
Publication year - 2008
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2008.00739.x
Subject(s) - benzimidazole , quantitative structure–activity relationship , carboxamide , chemistry , pharmacology , stereochemistry , computational biology , combinatorial chemistry , medicine , biology , organic chemistry
Quantitative structure–activity relationship of the 2‐(1‐propylpiperidin‐4‐yl)‐1H‐benzimidazole‐4‐carboxamide as a potent inhibitor of poly(ADP‐ribose) polymerase for cancer treatment was studied. A suitable set of molecular descriptors was calculated and the genetic algorithm was employed to select those descriptors that resulted in the best fitted models. Excellent results were obtained employing multiple linear regressions and critically discussed using a variety of statistical parameters. Furthermore, the model was validated using leave‐one‐out and leave‐ group‐out cross‐validation, external test set and chance correlation. A genetic algorithm‐multiple linear regression model with seven selected descriptors was obtained. This model, with high statistical significance ( R 2 = 0.935, = 0.894, = 0.875, F = 53.481), could be used to predict poly(ADP‐ribose) polymerase inhibitor activity of the molecules.