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Novel Aminomethylindole Derivatives as Inhibitors of pp60 c‐Src Tyrosine Kinase: Synthesis and Biological Activity
Author(s) -
İşgör Yasemin G.,
Kılıç Zuhal,
Ölgen Süreyya
Publication year - 2008
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2008.00734.x
Subject(s) - proto oncogene tyrosine protein kinase src , tyrosine kinase , tyrosine protein kinase csk , kinase , small molecule , chemistry , receptor tyrosine kinase , cancer research , signal transduction , microbiology and biotechnology , biology , biochemistry , sh2 domain
The pp60 c‐Src is one of the ubiquitously expressed Src family kinases and has important functions in malignant cells, including regulation of cell division, growth factor signaling, and movement. Therefore, investigating new small molecule inhibitors of pp60 c‐Src is important to discover and develop novel therapeutics for cancer and metastasis. Moreover, some of the small molecule inhibitors that do not qualify for therapeutic use may become very useful tool to explore the role of Src kinase in normal cells as well as in a variety of disease models. Our continuous efforts to find novel inhibitors of pp60 c‐Src aimed for therapeutic and research use, we synthesized newly designed aminomethylindole derivatives as novel small molecule inhibitors and investigated their inhibitory effect on pp60 c‐Src tyrosine kinase. Here, we report one potential inhibitor of the pp60 c‐Src from five active molecules of all nine compounds, which were synthesized and screened for the biological activity of the molecules against pp60 c‐Src target.