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Natural Compounds: Leads or Ideas? Bioinspired Molecules for Drug Discovery
Author(s) -
Beghyn Terence,
DeprezPoulain Rebecca,
Willand Nicolas,
Folleas Benoit,
Deprez Benoit
Publication year - 2008
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2008.00673.x
Subject(s) - drug discovery , natural (archaeology) , natural compound , combinatorial chemistry , chemistry , pharmacopoeia , computational biology , biochemical engineering , biology , medicine , biochemistry , engineering , paleontology , alternative medicine , pathology
In this article, we compare drugs of natural origin to synthetic compounds and analyze the reasons why natural compounds occupy a place of choice in the current pharmacopoeia. The observations reported here support the design of synthetic compounds inspired from plant alkaloids and their biosynthetic pathway. Our reasoning leads to very efficient syntheses of compounds which complexity matches that of indolomonoterpenic alkaloids.