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Structure–Function Relationship Research of Glycerol Backbone‐Based Cationic Lipids for Gene Delivery
Author(s) -
Liu Dongliang,
Qiao Weihong,
Li Zongshi,
Chen Yanxiang,
Cui Xiuyun,
Li Kun,
Yu Lihua,
Yan Kelu,
Zhu Limin,
Guo Yuliang,
Cheng Lvbo
Publication year - 2008
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2008.00644.x
Subject(s) - cationic polymerization , transfection , glycerol , chemistry , gene delivery , cationic liposome , liposome , ammonium , function (biology) , biochemistry , biophysics , combinatorial chemistry , organic chemistry , gene , biology , microbiology and biotechnology
Transfection activities of two series of synthetic glycerol backbone‐based cationic lipids were studied as gene delivery carriers. The variable length of hydrocarbon chains, diverse quaternary ammonium heads, different linkage, as well as alternative anion combined with them allowed to find how these factors affect cationic lipids on their gene delivery performance. The structure–function relationship of the synthetic glycerol backbone‐based cationic lipids was discussed, and the transfection efficiency of some of the cationic liposomes was superior or parallel to that of two commercial transfection agents.