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Synthesis of Novel 3‐Butyl‐2‐Substituted Amino‐3 H ‐Quinazolin‐4‐ones as Analgesic and Anti‐inflammatory Agents
Author(s) -
Alagarsamy V.,
Meena S.,
Ramaseshu K. V.,
Solomon V. Raja,
Kumar T. Durai Ananda,
Thirumurugan K.
Publication year - 2007
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2007.00548.x
Subject(s) - diclofenac sodium , analgesic , chemistry , anti inflammatory , aspirin , pharmacology , stereochemistry , medicinal chemistry , biochemistry , chromatography , medicine
A variety of novel 3‐butyl‐2‐substituted amino‐3 H ‐quinazolin‐4‐ones were synthesized by reacting the amino group of 3‐butyl‐2‐hydrazino‐3 H ‐quinazolin‐4‐one with various aldehydes and ketones. The title compounds were investigated for analgesic, anti‐inflammatory and ulcerogenic index activities. The compound 3‐butyl‐2‐(1‐methylbutylidene‐hydrazino)‐3 H ‐quinazolin‐4‐one ( AS3 ) emerged as the most active analgesic agent. Compound 3‐butyl‐2‐(1‐ethylpropylidene‐hydrazino)‐3 H ‐quinazolin‐4‐one ( AS2 ) emerged as the most active anti‐inflammatory agent and is moderately more potent when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to aspirin.