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The Antimicrobial Peptide PR‐39 has a Protective Effect Against HeLa Cell Apoptosis
Author(s) -
Ross Christopher R.,
Ricevuti Giovanni,
Scovassi Anna Ivana
Publication year - 2007
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2007.00540.x
Subject(s) - hela , apoptosis , cytotoxic t cell , cathelicidin , antimicrobial , bleomycin , etoposide , chemistry , cell , cell culture , microbiology and biotechnology , peptide , biology , cancer research , biochemistry , antimicrobial peptides , in vitro , chemotherapy , genetics
PR‐39 is a cathelicidin with antimicrobial properties, which acts as a suppressor of inflammation and exerts a number of additional activities. We investigated for the first time the effect of PR‐39 on human cells, by addressing the possible interference with HeLa cell metabolism. We observed that the continuous administration of PR‐39 to HeLa cell cultures was not cytotoxic and did not interfere with DNA synthesis. When used in combination with a panel of drugs inducing apoptosis through different mechanisms of action, i.e. etoposide, bleomycin, tert ‐butylhydroperoxide and 2‐deoxy‐ d ‐ribose, PR‐39 attenuated the apoptotic response of HeLa cells.