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Promises of Biomarkers in Drug Development – A Reality Check
Author(s) -
Marrer Estelle,
Dieterle Frank
Publication year - 2007
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2007.00522.x
Subject(s) - drug development , biomarker , marketing buzz , biomarker discovery , drug , identification (biology) , computer science , drug discovery , data science , risk analysis (engineering) , medicine , bioinformatics , pharmacology , biology , biochemistry , botany , proteomics , world wide web , gene
Biomarkers have been a buzz word in drug development for the last 5 years. But where do we stand now? This perspective article will demonstrate to which extent biomarkers have impacted drug development and the use of drugs. In particular, the different types of biomarkers, their identification, validation and use in different phases of drug development from drug discovery, to approval, to clinical application will be discussed as well as the state‐of‐the‐art biomarker technologies and promising future methods. The high interest in biomarkers has generated the need for development of new technologies and refinement of existing ones. Besides discussing their perspectives of applications, the present article also illustrates the future of biomarker development in terms of qualification for regulatory use and co‐development.