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Ab Initio Study of Non‐Peptidic Antihypertensives
Author(s) -
Jain Swati,
Yadav Arpita
Publication year - 2007
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2007.00503.x
Subject(s) - antagonism , chemistry , conformational isomerism , ab initio , substrate (aquarium) , receptor , stereochemistry , angiotensin ii , vasoconstriction , pharmacology , biophysics , computational chemistry , biochemistry , biology , molecule , endocrinology , organic chemistry , ecology
In this study, the authors report ab initio molecular orbital calculations on natural hormone angiotensin II (ANG II) that induces activity at AT 1 receptor leading to vasoconstriction and subsequent hypertension. Optimized conformations and charge distributions of various conformers of natural hormone and AT 1 antagonists have been studied. The major pharmacophoric features have been deduced. The charge environment of ANG II and drugs guided us in exploring the two possibilities: substrate inhibition and competitive inhibition. The results indicate that more potent drugs avoid ‘wastage’ in substrate inhibition and undergo strong competitive antagonism at the receptor. Specific binding interactions are essential for competitive antagonism. Slight differences in conformation may effect to differences in interactions with the receptor, hence modulating the antagonistic properties of the drug.