Characterization of Tachykinin‐related Peptides from Different Insect Species on  Drosophila  Tachykinin Receptor‐expressing Cell Line | Zendy

Fichna Jakub | Zendy; Poels Jeroen | Zendy; Broeck Jozef Vanden | Zendy; Janecka Anna | Zendy

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Characterization of Tachykinin‐related Peptides from Different Insect Species on Drosophila Tachykinin Receptor‐expressing Cell Line

Author(s) -

Fichna Jakub,

Poels Jeroen,

Broeck Jozef Vanden,

Janecka Anna

Publication year - 2006

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/j.1747-0285.2006.00441.x

Subject(s) - tachykinin receptor , drosophila melanogaster , aequorin , receptor , biology , calliphora , microbiology and biotechnology , biochemistry , agonist , neuropeptide , substance p , chemistry , intracellular , botany , gene , larva

Drosophila tachykinin receptor, a neurokinin receptor cloned from the fruit fly Drosophila melanogaster , is a G‐protein‐coupled receptor, which upon activation by a peptide agonist induces a transient increase in the concentration of intracellular calcium. The functional assay based on aequorin‐derived luminescence triggered by receptor‐mediated changes in Ca 2+ levels was used to examine and compare the effect of tachykinin‐related peptides from different species. Among the endogenous Drosophila peptides, Drm ‐TK I induced the strongest calcium response. The most potent tachykinin‐related peptides from Leucophaea maderae , Locusta migratoria , and Calliphora vomitoria , were partial agonists at the Drosophila tachykinin receptor.

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