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Discovery of Diphenylmethanepropionic and Dihydrostilbeneacetic Acids as Antagonists of the Integrin α v β 3
Author(s) -
Nagarajan Srinivasan R.,
Meyer Jane M.,
Miyashiro Julie M.,
Engleman V. Wayne,
Freeman Sandra K.,
Griggs David W.,
Klover Jon A.,
Nickols G. Alan
Publication year - 2006
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2006.00344.x
Subject(s) - peptidomimetic , integrin , drug discovery , chemistry , stereochemistry , combinatorial chemistry , biochemistry , receptor , peptide
A peptidomimetic inhibitor of the integrin α v β 3 has been substantially modified to produce several new nonpeptidic antagonists. These inhibitors are simpler to synthesize and belong to new classes of scaffolds. Some of the compounds served as the initial lead for further optimization, which led to the discovery of potent and selective inhibitors of the integrin α v β 3 .