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Fluorescent Indolylboronic Acids that are Useful Reporters for the Synthesis of Boronolectins
Author(s) -
Wang Junfeng,
Jin Shan,
Lin Na,
Wang Binghe
Publication year - 2006
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2005.00338.x
Subject(s) - fluorescence , lectin , chemistry , biochemistry , combinatorial synthesis , boronic acid , combinatorial chemistry , physics , quantum mechanics
Lectins are known to regulate a wide variety of biological processes. Therefore, small molecule mimics of lectins have the potential to be used as novel diagnostic and therapeutic agents. In our combinatorial search for lectin mimics, we are in need a large number of boronic acids that change fluorescent properties upon carbohydrate binding. Along this line, a series of indolylboronic acids have been found to show significant fluorescent property changes upon binding with carbohydrates in 0.1 M phosphate buffer at physiological pH. These boronic acids will be very useful for the synthesis of lectin mimics for biological applications.