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Biochemical Microarrays for Studying Chemical Biology Interaction: DiscoveryDot TM Technology
Author(s) -
Horiuchi Kurumi Y.,
Wang Yuan,
Ma Haiching
Publication year - 2006
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2005.00326.x
Subject(s) - proteases , dna microarray , context (archaeology) , serine , cysteine , histone , computational biology , chemical biology , drug discovery , chemistry , biochemistry , enzyme , biology , gene expression , gene , paleontology
DiscoveryDot TM is a novel solution‐phase technology for chemical compound microarrays which has been validated for several targets (e.g. serine proteases, cysteine proteases, metalloproteinases, histone deacetylases, phosphatases and various kinases) of significance for drug discovery. The historical context of microarrays and the advantages of the DiscoveryDot TM technology are highlighted. The success of this chemical microarray technology will provide unprecedented possibility and capability for parallel functional analysis of hundreds of thousands of chemical compounds.