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A Chemogenomic Approach to Discovering Target‐Selective Drugs
Author(s) -
Janzen William P.,
Hodge C. Nicholas
Publication year - 2006
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2005.00325.x
Subject(s) - drug discovery , timeline , computer science , drug development , process (computing) , computational biology , drug , data mining , pharmacology , bioinformatics , medicine , biology , archaeology , history , operating system
An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high‐quality high‐throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from ‘hit’ to ‘lead’ stage, and should reduce liabilities for a molecule advancing through the development process.