Premium
Bioavailability of selenium from selenium‐enriched milk assessed in the artificially reared neonatal pig
Author(s) -
UGLIETTA Raffaele,
DOYLE Peter T.,
WALKER Glen P.,
HEARD Joanna W.,
LEDDIN Clare M.,
STOCKDALE C. Richard,
MCINTOSH Graeme H.,
YOUNG Graeme P.,
DUNSHEA Frank R.
Publication year - 2008
Publication title -
nutrition and dietetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.479
H-Index - 31
eISSN - 1747-0080
pISSN - 1446-6368
DOI - 10.1111/j.1747-0080.2008.00259.x
Subject(s) - selenium , bioavailability , zoology , selenate , selenoprotein , dry matter , food science , chemistry , biology , glutathione peroxidase , endocrinology , oxidative stress , pharmacology , catalase , organic chemistry
There is interest in pre‐farm gate fortification of the diet with highly bioavailable selenium (Se) to improve public health, so the aim of the present study was to determine the bioavailabilities of Se from Se‐enriched whole milk and milk replacers supplemented with exogenous Se in neonatal pigs. Milk enriched with Se (1070 μg Se/kg dry matter (DM); HSeM) was obtained from cows supplemented with selenised yeast while the control milk diet (135 μg Se/kg DM; LSeM) was made using milk powder from non‐supplemented cows. Additional diets were formulated by adding selenised yeast (HSP) or selenate (HSN) to the LSeM diet to give final Se concentrations of 1070 μg Se/kg DM. Neonatal pigs were trained to drink milk and then randomly allocated to their four respective diets and slaughter times (0, 7, 14, 28 and 42 days of feeding). Plasma Se increased over the first 21 days in pigs consuming HSeM, reaching a value over three times higher than the LSeM pigs. Plasma Se concentrations plateaued at 45, 125, 122 and 170 μg/mL for LSeM, HSN, HSP and HSeM pigs, respectively ( P < 0.001). After 28 days, muscle Se plateaued at 47, 106, 237 and 486 μg/kg for LSeM, HSN, HSP and HSeM pigs, respectively ( P < 0.001). Colonic selenoprotein P gene expression was greater ( P = 0.024) in pigs fed HSeM compared with LSeM while the HSP and HSN were intermediate. These data suggest that Se in milk from cows fed selenised yeast is highly bioavailable and may offer a means of delivering supplemental Se to humans.