Open AccessOral magnesium supplementation in adults with coronary heart disease or coronary heart disease risk
Author(s) -
Mathers Tavia W.,
Beckstrand Renea L.
Publication year - 2009
Publication title -
journal of the american academy of nurse practitioners
Language(s) - English
Resource type - Journals
eISSN - 1745-7599
pISSN - 1041-2972
DOI - 10.1111/j.1745-7599.2009.00460.x
Subject(s) - medicine , magnesium , adverse effect , randomized controlled trial , magnesium deficiency (plants) , coronary heart disease , heart disease , cardiology , materials science , metallurgy
Purpose: To review randomized control clinical trial (RCT) literature and prospective studies for the safety and efficacy of magnesium supplements in patients with coronary heart disease (CHD) or with CHD risk. Data sources: Databases were searched using the keywords: magnesium, heart disease, endothelium, prevention, treatment, therapy, level, and supplement. Conclusions: There were no reports of adverse effects from magnesium supplementation in any of the studies. Subjects reporting lower dietary magnesium intake had significantly lower serum magnesium concentrations than those reporting higher dietary magnesium intake and, in some cases, had a significantly higher frequency of supraventricular beats. There was a modest relationship between dietary magnesium intake and a reduced risk of CHD in male subjects; however, there was no noted decrease in the development of CHD disease in women who had high magnesium intake. Implications for practice: Magnesium is vital for many functions in the body and magnesium supplementation is safe. There is a possible association between a modestly lower risk of CHD in men and increased magnesium intake; therefore, it is reasonable to encourage diets high in magnesium as a potential means to lower the risk of CHD.