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ASSESSMENT OF THE SPREADABILITY OF OFFICIAL PHARMACEUTICAL CREAMS AND OINTMENTS USING THE MASTER CURVE CONCEPT
Author(s) -
BARRY B. W.,
MEYER M. C.
Publication year - 1975
Publication title -
journal of texture studies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.593
H-Index - 54
eISSN - 1745-4603
pISSN - 0022-4901
DOI - 10.1111/j.1745-4603.1975.tb01419.x
Subject(s) - spreadability , cosmetics , viscometer , materials science , mathematics , chromatography , chemistry , viscosity , composite material , food science , organic chemistry
. Spreadability characteristics of official creams and ointments of the British Pharmacopoeia and the British Pharmaceutical Codex were determined using the Master Curve concept and continuous shear data. Experimental results were obtained using a Ferranti‐Shirley cone and plate viscometer at 25 d̀C and 34 d̀C, representing an approximate temperature range encountered during spreading of topical preparations. Data derived for creams intersected the Master Curve in the preferred region, although not at the optimum value. Ointments demonstrated large variations in spreading properties. The variation and lack of optimum spreadability characteristics were explained by considering the medicinal criteria required of topical pharmaceutical products as distinct from cosmetics.