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DEVELOPMENT AND EVALUATION OF A RISK ASSESSMENT TOOL FOR CONTROL OF ANTIMICROBIAL DRUG RESIDUES IN MILK
Author(s) -
SHITANDI ANAKALO,
KIHUMBU GATHONI
Publication year - 2004
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.2004.tb00384.x
Subject(s) - antimicrobial , antimicrobial drug , risk assessment , residue (chemistry) , drug , medicine , contamination , cohort , environmental health , microbiology and biotechnology , biology , pharmacology , computer science , ecology , biochemistry , computer security
This study evaluated a developed risk assessment tool for control of antimicrobial residues in milk within Kenya. Eleven risk characteristics predicting residue contamination were identified and assessed from farms (n = 184), of which five were associated with a higher residue risk (P < 0.05). A score (0–5) was derived for each of the five factors and a ± 3 score used to define high risk. The tool was validated on farms (n = 100) in a local and remote cohort study and observed to have a 91% sensitivity and 75% specificity. The risk of violative antimicrobial drug residues in milk supplies decreased by 52% (P < 0.05) when the risk tool was applied in a single blind randomized control study on farms (42 cases and 42 controls). The risk assessment tool was concluded to offer good potential of being used within a control program to minimize violative antimicrobial drug residues in farm milk.