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EVALUATION OF THE TOXICITY OF LACTOBACILLUS ACIDOPHILUS LAP5 IN A 28‐DAY FEEDING STUDY IN WISTAR RATS
Author(s) -
TSAI CHENGCHIH,
CHEN MINGHUI,
LIU TSENGHUANG,
CHAU CHINGIN,
CHANG LITUNG,
TSAI CHINCHUAN,
TSEN HAUYANG
Publication year - 2004
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.2004.00542.x
Subject(s) - lactobacillus acidophilus , toxicity , strain (injury) , lactic acid , food science , biology , hematology , probiotic , adverse effect , lactobacillus , physiology , microbiology and biotechnology , pharmacology , bacteria , medicine , fermentation , immunology , anatomy , genetics
We have previously screened lactic acid bacteria strains from porcine intestine and evaluated their functional properties. We found a strain of Lactobacillus acidophilus LAP5 is with potential for use as human and animal probiotics. However, the safety of the strain in consideration must be evaluated. The present study was conducted to evaluate the toxicity of strain L. acidophilus LAP5 in Wistar rats by dietary administration at concentrations of 2.1 × 10 11 , 1.05 × 10 11 and 4.2 × 10 9 CFU per kg body weight of rat per day for 28 days. There were no adverse effects on the general condition and behavior, growth, feed and water consumption, hematology, clinical chemistry indexes, organ weights and histopathologic analysis. Results of this study demonstrated that consumption of strain L. acidophilus LAP5 was not associated with any signs of toxicity in Wistar rats even following consumption of large quantities.