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RELATIONSHIP BETWEEN FOODBORNE BACTERIAL PATHOGENS AND THE REACTIVE ARTHRITIDES
Author(s) -
SMITH JAMES L.,
PALUMBO SAMUEL A.,
WALLS ISABEL
Publication year - 1993
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1993.tb00107.x
Subject(s) - reactive arthritis , molecular mimicry , ankylosing spondylitis , etiology , yersinia , hla b27 , medicine , immunology , shigella , arthritis , campylobacter jejuni , salmonella , antigen , microbiology and biotechnology , biology , human leukocyte antigen , pathology , bacteria , genetics
Certain individuals suffer complications after diarrheic episodes caused by Campylobacter, Salmonella, Shigella, or Yersinia. One of these complications may be a sterile arthritis such as reactive arthritis, Reiter's syndrome and anklylosing spondylitis. Reactive arthritis and Reiter's syndrome have been shown to have a bacterial etiology; however, such etiology, while suspected, has not been definitely confirmed for ankylosing spondylitis. These arthritides show a strong familial assocation and here, reactive arthritis, Reiter's syndrome and ankylosing spondylitis are characterized and the relationship of the diseases to the major histocompatility complex antigen, HLA‐B27, is described. Studies have indicated that there may be molecular mimicry between certain microbial antigens and HLA‐B27. Molecular mimicry is discussed in terms of its possible explanation of the etiology of the reactive arthritides. The roles of antibodies, lymphocytes, bacterial antigens, and stress proteins in the symptomology of the arthritides are reviewed .