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LIPOPOLYSACCHARIDE — PROTEIN COMPLEX AS POTENT VACCINE AGAINST SALMONELLOSIS
Author(s) -
CHANDER RAMESH,
LEWIS NORMAN F.
Publication year - 1986
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1986.tb00555.x
Subject(s) - lipopolysaccharide , immunization , salmonella , microbiology and biotechnology , antigen , immunity , biology , chemistry , immune system , bacteria , immunology , genetics
Lipopolysaccharide‐protein (LPS‐P) vaccine prepared from cells of S. typhimurium contains 11% protein. Immunization of mice with LPS‐P intraperitoneally at a dose level of 50 μg/mouse conferred 100% protection against subsequent challenge with S. typhimurium and seven other strains of Salmonella each possessing typical O‐antigen determinants. The immunity lasts for six months and the vaccine is equally effective in all six strains of mice studied. The lyophilized LPS‐P preparation is stable for eighteen months, thus providing opportunity for large scale field trial experiments.