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KINETIC STUDY OF T‐2 TOXIN METABOLITES IN A COW
Author(s) -
CHATTERJEE KAJAL,
PAWLOSKY ROBERT J.,
TREEFUL LINDA,
MIROCHA C. J.
Publication year - 1986
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1986.tb00549.x
Subject(s) - toxin , urine , chemistry , chromatography , kidney , endocrinology , biology , biochemistry
A Holstein cow was given a single, oral dose of T‐2 toxin (200 mg), and blood and urine samples were collected at regular time intervals for 48 h. The animal was dosed once more with the same amount and samples were again collected over another 48 h period. Trace amount (2 ppb) of T‐2 toxin was detected in the blood up to 24 h as well HT‐2, TC‐3, and T‐2 tetraol. De‐epoxy‐T‐2‐tetraol was detected in the blood and urine up to 48 h. No T‐2 could be found in the urine but HT‐2, TC‐1, TC‐3 and T‐2‐tetraol were detected. In addition, three major metabolites, i.e., iso TC‐1, de‐epoxy‐TC‐3 and de‐epoxy‐T‐2 tetraol, were found in the urine. Production of these metabolites was maximum at 14–20 h after administration of the toxin. No substantial accumulation of T‐2 toxin derivatives were found in the lung, heart, liver or kidney when the cow was sacrificed at the end of the experiment.