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TOXICITY OF 1, 2‐DIMETHYLHYDRAZINE IN MICE: EFFECT OF DIET AND DEVELOPMENT OF TOLERANCE
Author(s) -
TEMPLE N. J.,
ELKHATIB S. M.
Publication year - 1985
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1985.tb00499.x
Subject(s) - 1,2 dimethylhydrazine , dimethylhydrazine , bran , nutrient , chemistry , toxicity , food science , zoology , biology , medicine , colorectal cancer , raw material , organic chemistry , cancer
The effect of diet on the lethality of 1, 2‐dimethylhydrazine (DMH) injections was investigated using Swiss mice. Mortality was highest when mice were fed a nutrient‐diluted/high‐fat diet, was intermediate with a nutrient‐diluted/low‐fat diet and was lowest with laboratory chow. Wheat bran was not protective. Mice developed tolerance to DMH after receiving several injections of progressively increasing dose.