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EVALUATION OF POLY (HEXAMETHYLENE BIGUANIDE. HC1) AS A BIOCIDE IN THE FOOD INDUSTRY
Author(s) -
ROSENTHAL IONEL,
JUVEN BENJAMIN J.,
BENHUR EHUD
Publication year - 1982
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1982.tb00444.x
Subject(s) - biguanide , disinfectant , biocide , chemistry , reagent , staphylococcus aureus , pseudomonas aeruginosa , hydrochloride , escherichia coli , nuclear chemistry , bacillus cereus , food industry , food additive , microbiology and biotechnology , food science , bacteria , organic chemistry , biochemistry , biology , genetics , metformin , insulin , gene
Poly (hexamethylene biguanide hydrochloride) (PHMB), an industrial disinfectant, was evaluated for potential use in the food industry following suggestions in the literature. A colorimetric test based on the reaction with nitro‐prusside reagent was found suitable for the dosimetry of this compound. In a bacteriological medium, at a concentration of 20 μg/ml, PHMB was inhibitory to Escherichia coli, less effective against Staphylococcus aureus, and practically ineffective against Pseudomonas aeruginosa. The bactericidal activity of PHMB was impaired in the presence of milk but little affected upon the addition of blood. Finally, in a toxicological test in vitro, PHMB was found to be toxic toward Chinese hamster cells, at doses similar to those required for antibacterial activity.