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AMELIORATION OF TOXIC EFFECTS OF ETHYLIDENE GYROMITRIN (FALSE MOREL POISON) WITH PYRIDOXINE CHLORIDE
Author(s) -
WRIGHT ATTE,
NISKANEN AIMO,
PYYSALO HEIKKI,
KORPELA HEIKKI
Publication year - 1981
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1981.tb00422.x
Subject(s) - pyridoxine , chemistry , vitamin , vitamin c , chloride , vitamin b6 , medicine , pharmacology , biochemistry , organic chemistry
Repeated (five) doses of pyridoxine chloride (vitamin B 6 , 10 mg) reduced botht he neurological symptoms caused by ethylidene gyromitrin, the main poisonous compound of the mushroom false morel (Gyromitra esculenta pers. Fr.), and the overall mortality due to ethylidene gyromitrin poisoning in mice treated orally with this poison (400 mg/kg). In contrast, little or no effect was found when the mice were treated with γ‐aminobutyric acid (1 mg) or vitamin C (10 mg) after treatment with poison. The significance of these findings is discussed in perspective to possible treatments of human poisonings caused by false morel.