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TISSUE DISTRIBUTION OF 14 C‐SULFAMETHAZINE RESIDUES IN SWINE
Author(s) -
DePAOLIS ANNELI M.,
MAHER MAUREEN,
KATZ STANLEY E.,
ROSEN JOSEPH D.
Publication year - 1980
Publication title -
journal of food safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 43
eISSN - 1745-4565
pISSN - 0149-6085
DOI - 10.1111/j.1745-4565.1980.tb00535.x
Subject(s) - loin , kidney , chemistry , tissue distribution , pig liver , drug , chromatography , liver tissue , pharmacology , medicine , food science , biochemistry , enzyme
14 C‐Sulfamethazine was administered to Yorkshire‐Hampshire pigs and the amount of radioactivity present in liver, kidney, shoulder, rear leg, loin, fat and blood was determined in pigs sacrificed 0.125, 2, 5, 10, and 15 days after withdrawal of the drug. Rapid depletion of the drug was observed from all tissues. Liver was the site of the largest concentration of radioactivity, containing an average of 30.2 and 10.1 ppb sulfamethazine (assuming all radioactivity due to parent drug) after 10 and 15 days withdrawal, respectively. Thin‐layer chromatography of liver, shoulder and kidney tissues revealed that the major portion of the radioactivity was due to metabolites.