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ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF GARCINIA INDICA CHOISY FRUITS IN CARBON TETRACHLORIDE‐INDUCED LIVER INJURY IN RATS
Author(s) -
PANDA VANDANA SANJEEV,
ASHAR HARDIK DIPAKKUMAR
Publication year - 2012
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/j.1745-4514.2010.00531.x
Subject(s) - hepatoprotection , carbon tetrachloride , lipid peroxidation , antioxidant , chemistry , superoxide dismutase , glutathione reductase , catalase , glutathione , pharmacology , traditional medicine , malondialdehyde , glutathione peroxidase , biochemistry , liver injury , biology , medicine , enzyme , organic chemistry
The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) on carbon tetrachloride (CCl 4 )‐induced hepatotoxicity were investigated in rats. GIE (400 mg/kg and 800 mg/kg) and the reference drug silymarin (100 mg/kg) were administered orally for 10 days to rats treated with CCl 4 for 7 days. GIE and silymarin elicited significant hepatoprotective activity by attenuating the CCl 4 ‐elevated levels of serum marker enzymes (aspartate aminotransferase and alanine aminotransferase) and malondialdehyde, and restoring the CCl 4 ‐depleted levels of reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in liver. GIE 800 mg/kg demonstrated greater hepatoprotection than GIE 400 mg/kg. The present findings indicate that hepatoprotective effects of GIE in CCl 4 ‐induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation in liver. PRACTICAL APPLICATIONS Garcinia indica Choisy is an Indian plant, the fruit of which is widely used in cooking and has many pharmaceutical and industrial uses. It has been shown to possess a wide range of medicinal properties and many of its therapeutic effects are described in Ayurveda. Traditionally, the syrup of G. indica fruit has been administered to alcohol‐intoxicated individuals for protection of liver. Literature reports the aqueous extracts of G. indica fruit rind to possess potent antioxidant, free radical scavenging and anti‐lipid peroxidative activities. The present study evaluates the hepatoprotective effect of G. indica fruit with an aim to bring about value addition to its health benefits, establish it as a potent “functional food” and promote its use as a culinary spice to enrich people's diets. Besides, it is cheap and readily available to all strata of society.