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EFFECTS OF DEEP‐SEA WATER ON CARDIAC ABNORMALITY IN HIGH‐CHOLESTEROL DIETARY MICE
Author(s) -
SHEN JUILUNG,
HSU TSAICHING,
CHEN YICHEN,
HSU JENGDONG,
YANG LIENCHUAN,
TSAI FUUJEN,
LI CHENGCHIEN,
CHENG YAWEN,
HUANG CHIHYANG,
TZANG BORSHOW
Publication year - 2012
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/j.1745-4514.2010.00498.x
Subject(s) - cholesterol , medicine , high cholesterol , high density lipoprotein , triglyceride , endocrinology
Our recent studies indicated that electrodialysed deep‐sea water (ED‐DSW) revealed the cardiovascular health effects, such as hindrances of the dietary‐induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh‐density‐lipoprotein cholesterol (HDL‐C), as well as improvement of HDL‐C/non‐HDL‐C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED‐DSW on high‐cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis and enhancing insulin‐like growth factor‐1 receptor (IGF‐1R) cardiac survival signaling compared with those mice that were treated with distilled water, reverse osmosis (RO)‐DSW or 10% (v/v) dilution with ddH2O (10% DSW). These findings further clarified the possible mechanisms of cardiac protective effects of ED‐DSW and might suggest ED‐DSW as an ingredient of cardiovascular health food in some niche markets. PRACTICAL APPLICATIONS Deep‐sea water (DSW) has been applied on several fields including aquaculture, agriculture, food processing, cosmetics and medicine. Recently, we have indicated that high‐cholesterol dietary mice drinking electrodialysed DSW (ED‐DSW) showed decreased serum lipids, blood pressure and improving blood cholesterol profile. In this study, we further demonstrated the beneficial effects of ED‐DSW on high‐cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis in left ventricle and increasing cardiac survival signaling, such as insulin‐like growth factor‐1 receptor, phosphoinositide‐3‐kinases and p‐AKT/AKT ratio. Altogether, these findings indicated that ED‐DSW revealed the cardiac protective effects and might be suggested as an ingredient of cardiovascular health food in a variety of niche markets.