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HEME IRON POLYPEPTIDE POLYMER WITH HIGH IRON CONTENT AS AN IDEAL IRON SUPPLEMENT
Author(s) -
PARK KWANGHYUN,
KIM HYUNSU,
HAN MYUNGKWAN,
KIM UHHYUN
Publication year - 2010
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/j.1745-4514.2010.00342.x
Subject(s) - hemoglobin , population , anemia , polymer , iron deficiency anemia , solubility , chemistry , hepcidin , absorption (acoustics) , iron deficiency , medicine , biochemistry , food science , materials science , organic chemistry , environmental health , composite material
Iron deficiency is a common nutritional problem and results in anemia in human population. Heme iron (HI) is known to be a better iron supplement than non‐HI because of its fewer gastrointestinal side effects. HI polypeptide (HIP) is prepared by enzymatic digestion of hemoglobin from animal blood and subsequent ultrafiltration or dialysis. Here we find a polymerized form of HIP with high iron content and provide an efficient method to prepare the HIP polymer. The molecular weight of the HIP polymer was around 250 kDa, which was determined by gel filtration. The polymer was soluble in a wide range of pH, and iron content was about 1.8%, that is the highest among any other forms of HIP. Moreover, when administered to healthy human, the polymer increased serum iron level twofold, 5 h after the administration. These data indicate that the HIP polymer containing high level of iron can be used as an ideal iron supplement in anemic patients.PRACTICAL APPLICATIONS Heme iron polypeptide (HIP) is an ideal iron supplement because of its good solubility and absorption while being less toxic to gastrointestinal cells. However, there are few reports on preparations of HIP from animal whole blood as a food supplement. The present study reports preparation and characterization of HIP polymer containing high level of iron from porcine blood. It is beneficial to utilize porcine whole blood, which is abundantly available at a low price. Therefore, it would provide a useful technique for mass production of the ideal iron supplement.