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WATER EXTRACTS FROM NELUMBO NUCIFERA LEAF REDUCED PLASMA LIPIDS AND ATHEROSCLEROSIS IN CHOLESTEROL‐FED RABBITS
Author(s) -
LEE HUEIJANE,
CHEN CHANGCHE,
CHOU FENPI,
WU CHENGHSUN,
LAI FUSHUN,
YANG MONYUNG,
WANG CHAUJONG
Publication year - 2010
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/j.1745-4514.2009.00315.x
Subject(s) - hyperlipidemia , triglyceride , cholesterol , in vivo , antioxidant , foam cell , chemistry , nelumbo nucifera , high density lipoprotein , biochemistry , lipoprotein , food science , biology , botany , endocrinology , lotus , diabetes mellitus , microbiology and biotechnology
Nelumbo nucifera Gaertn (Nelumbonaceae) leaf was used as food or beverage in Taiwan. Recently, the leaf extract was also found to possess antioxidative ability. Base on the close relationship between antioxidation and atherosclerosis, we investigated the inhibitory activity of the water extract ( Nelumbo nucifera leaf extract [NLE]) on hyperlipidemia and atherosclerosis. In rabbits fed with high‐cholesterol diet (HCD) plus 0.5% or 1.0% of NLE, the inhibitory level of triglyceride was 30% and 46.6%, and low‐density lipoprotein cholesterol (LDL‐C) was 45.4 and 45.9% compared with the HCD‐fed rabbits. NLE significantly reduced severe atherosclerosis, foam cell formation and smooth muscle cell proliferation and migration in the aorta. In the thiobarituric acid‐reacting substances assay, the concentration of NLE higher than 0.05 mg/mL, the inhibitory percentage was about 80%. In the relative electrophoretic mobility assay, NLE inhibited oxidative LDL up to 60%. These results suggest that NLE lowers LDL oxidation and serum lipids, and has cardiovascular protective ability.PRACTICAL APPLICATIONS The water extract of Nelumbo nucifera Gaertn (Nelumbonaceae) leaf can significantly inhibit oxidative low‐density lipoprotein in vitro and reduce plasma lipid, atherosclerosis, foam cell formation, and smooth muscle cell proliferation and migration in vivo . These findings point out that the water extract of Nelumbo nucifera Gaertn (Nelumbonaceae) leaf can be applied for preventing cardiovascular diseases.