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ANTIOXIDATIVE PROPERTY AND ANTIATHEROSCLEROTIC EFFECTS OF THE POWDER PROCESSED FROM CHAENOMELES SPECIOSA IN APOE –/– MICE
Author(s) -
TANG YONG,
YU XIAOPING,
MI MANTIAN,
ZHAO JING,
WANG JIAN,
ZHANG TING
Publication year - 2010
Publication title -
journal of food biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 47
eISSN - 1745-4514
pISSN - 0145-8884
DOI - 10.1111/j.1745-4514.2009.00297.x
Subject(s) - polyphenol , dpph , chemistry , food science , antioxidant , vitamin e , aortic sinus , vitamin c , cholesterol , traditional medicine , low density lipoprotein , biochemistry , medicine , aorta
This study was conducted to explore antioxidative property and antiatherosclerotic effects of the powder processed from Chaenomeles speciosa. Chaenomeles speciosa powder (CSP) was rich in vitamin C and polyphenols. The ferric reducing antioxidant power of CSP was 173 ± 7 µmol Fe 2+ /g and the scavenging activity on 1,1‐diphenyl‐2‐picrylhydrazyl free radical (DPPH•) and were 945 ± 20 µg DPPH•/g and 700 ± 21 U/mL, respectively. We further tested antiatherosclerotic effects of CSP in ApoE –/– mice which was fed a high‐fat diet for 16 weeks. Both 5 and 10% CSP dietary supplement significantly reduced serum low‐density lipoprotein cholesterol and total cholesterol levels ( P < 0.05). Comparing with normal group, there was a significant increase of glutathione peroxidase activity and total antioxidative capacity, and a reduction of relative atherosclerotic plaque area of aortic sinus and aortic arch in ApoE –/– mice supplemented with 5 and 10% CSP ( P < 0.05). Our results suggest that CSP has potent antioxidative ability and available antiatherosclerotic effects.PRACTICAL APPLICATIONS Chaenomeles speciosa has been cultivated widely in Chongqing for hundreds of years and it is also a traditional herb for the Chinese because of its many health preventive potentials. After effects of the processed powder with antioxidation and antiatherosclerotic were testified in our experiments, Chaenomeles speciosa powder can be considered as a beneficial dietary supplement for improving human health, especially in preventing atherogenesis, which does not due to the synergistic effect of antioxidants with more kinds of antioxidants substances, such as vitamin C.