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Selective Plasma Exchange With Dialysis in Patients With Acute Liver Failure
Author(s) -
Nakae Hajime,
Igarashi Toshiko,
Tajimi Kimitaka
Publication year - 2012
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2012.01112.x
Subject(s) - medicine , albumin , hepatic encephalopathy , dialysis , liver failure , gastroenterology , blood proteins , oxidative stress , hemodialysis , creatinine , blood plasma , cirrhosis
Selective plasma exchange with dialysis is a blood purification therapy in which simple plasma exchange is performed using a selective membrane plasma separator while the dialysate flows out of the hollow fibers. To evaluate the effect of plasma exchange with dialysis, biochemical examination of the blood, for example, the oxidative stress regulation system and interleukin 18 levels, was performed in patients with acute liver failure. We studied four patients with acute liver failure in whom the therapy was performed (nine times in total). The degree of hepatic encephalopathy and interleukin 18 levels decreased significantly after treatment. However, total protein levels did not change significantly. The level of reactive oxygen species and total antioxidant capacity did not change significantly. Plasma exchange with dialysis may be a useful blood purification therapy in cases of acute liver failure in terms of the removal of water‐soluble and albumin‐bound toxins.