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Bone Histology in Chronic Kidney Disease‐related Mineral and Bone Disorder
Author(s) -
Kazama Junichiro James
Publication year - 2011
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2011.00923.x
Subject(s) - medicine , histology , pathology , cancellous bone , bone remodeling , bone disease , bone mineral , chronic kidney disease mineral and bone disorder , kidney disease , renal osteodystrophy , bone histomorphometry , bone tissue , gold standard (test) , osteoporosis , radiology , trabecular bone
A quantitative histological analysis of biopsied bone samples is currently regarded as the gold standard for a diagnosing procedure for bone diseases associated with chronic kidney disease‐related mineral and bone disorder. Conventionally, “bone cell activities” and “bone mineralization” are applied as two independent assessment axes, and the histology results are classified into five categories according to these axes. Recently, a new bone histology classification system called the Turnover‐Mineralization‐Volume system, which applied “cancellous bone volume” as another major assessing axis, was advocated; however, both classification systems have many unsolved problems. Clinicians must realize the limitations in evaluating bone metabolism by bone histology. We will need to establish a new classification method for renal bone diseases independent of histological findings.