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A Case Report of Thrombocytopenia‐associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange
Author(s) -
Yildirim Inci,
Ceyhan Mehmet,
Bayrakci Benan,
Uysal Mutlu,
Kuskonmaz Baris,
Ozaltin Fatih
Publication year - 2010
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2009.00714.x
Subject(s) - medicine , salmonella typhi , ciprofloxacin , antimicrobial , sepsis , salmonella enterica , serotype , typhoid fever , regimen , intensive care medicine , immunology , salmonella , antibiotics , virology , microbiology and biotechnology , bacteria , biochemistry , chemistry , genetics , escherichia coli , biology , gene
A high proportion of the patients with Salmonella enterica serotype Typhi infection develop severe sepsis. The mortality rate is high despite aggressive antimicrobial therapy in these patients. The case of a 10‐year‐old boy who developed thrombocytopenia‐associated multiple organ failure (TAMOF) secondary to S. typhi infection is reported. The patient did not respond to antimicrobial treatment, including ciprofloxacin, in addition to conventional supportive measures, so plasma exchange was performed. The thrombocytopenia and organ failure had resolved after 3 days of plasma exchange therapy. Plasma exchange is suggested to be a life‐saving intervention in a child with TAMOF secondary to S. typhi infection.