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On‐line Hemodiafiltration in Southeast Asia: A Three‐year Prospective Study of a Single Center
Author(s) -
Tiranathanagul Khajohn,
Praditpornsilpa Kearkiat,
Katavetin Pisut,
Srisawat Nattachai,
Townamchai Natavudh,
Susantitaphong Paweena,
Tungsanga Kriang,
EiamOng Somchai
Publication year - 2009
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2009.00654.x
Subject(s) - medicine , center (category theory) , single center , southeast asia , line (geometry) , ancient history , chemistry , geometry , mathematics , history , crystallography
Abstract: Growing evidence suggests the superiority of on‐line hemodiafiltration (HDF) compared with the conventional hemodialysis technique in many aspects; however, on‐line HDF is still not used worldwide, including in Southeast Asia. The purpose of this study is to compare various clinical outcomes between on‐line HDF and high‐flux hemodialysis (HFHD). This was a single‐center three‐year prospective observational study that demonstrated the clinical parameters after switching from HFHD to on‐line HDF in 22 HDF patients, whose average age was 58.1 ± 13.3 years. The incidence of intradialytic undesired events, including hypotension, decreased and an apparent increase in appetite and an improvement in overall well‐being were recorded by most patients after switching to on‐line HDF. The data for dry weight, body mass index, and normalized protein nitrogen appearance, which represent nutritional status, showed a significant improvement while still maintaining a satisfactory albumin level. The adequacy in terms of urea reduction ratio significantly increased. The serum predialysis β 2 ‐microglobulin levels were reduced by 25.7% from 31.1 ± 3.1 to 23.1 ± 4.8 mg/L ( P < 0.05) at six months and remained constant during the three years of follow‐up. The patients' lipid profile was well controlled, and the mean C‐reactive protein value was still maintained in the normal range. In conclusion, our three‐year experience showed that on‐line HDF is a well‐tolerated treatment with a lower incidence of intradialytic undesired events. The potential benefits may include the effective removal of higher molecular weight uremic toxins and an improved nutritional status, along with a low inflammatory state.