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Association of Heart Valve Calcification With Malnutrition‐Inflammation Complex Syndrome, β 2 ‐Microglobulin, and Carotid Intima Media Thickness in Patients on Hemodialysis
Author(s) -
Ikee Ryota,
Honda Kenjiro,
Oka Machiko,
Maesato Kyoko,
Mano Tsutomu,
Moriya Hidekazu,
Ohtake Takayasu,
Kobayashi Shuzo
Publication year - 2008
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2008.00636.x
Subject(s) - medicine , calcification , hemodialysis , cardiology , beta 2 microglobulin , population , diabetes mellitus , gastroenterology , endocrinology , environmental health
Heart valve calcification is an important predictor for all‐cause and cardiovascular mortality in hemodialysis patients. Recently, serum β 2 ‐microglobulin has been associated with cardiovascular disease in the non‐hemodialysis population, but the relationship between serum β 2 ‐microglobulin and valve calcification remains unknown. In this cross‐sectional study, we recorded the patients' clinical parameters, including serum β 2 ‐microglobulin, and related these parameters to the number of calcified valves detected by echocardiography. The patients included 80 males and 35 females (age 67 ± 10 years; duration on hemodialysis 96 ± 67 months). Calcification of the aortic and mitral valves was observed in 89 (77.4%) and 59 patients (51.3%), respectively. Fifty‐one patients (44.3%) showed calcification of both valves. In univariate analysis, age ( r = 0.301, P = 0.001), serum albumin ( r = −0.219, P = 0.01), calcium ( r = 0.205, P = 0.02), high sensitivity C‐reactive protein ( r = 0.209, P = 0.02), and β 2 ‐microglobulin ( r = 0.206, P = 0.02) significantly correlated with the number of calcified valves. Stepwise multiple regression analysis showed that age (β = 0.389, P < 0.001) and calcium (β = 0.223, P = 0.01) were independent determinants for valve calcification ( r 2 = 0.195). In addition, carotid intima media thickness was significantly higher in patients with valve calcification compared with those without valve calcification. Our results suggested the impacts of calcium metabolism and malnutrition‐inflammation complex syndrome on valve calcification. In addition, serum β 2 ‐microglobulin may be another potential marker of cardiovascular complications in patients on hemodialysis.