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A Case Report of Nephrotic Syndrome Due to Collapsing Focal Segmental Glomerulosclerosis Treated With Low‐density Lipoprotein Apheresis
Author(s) -
Miyazono Motoaki,
Tomiyoshi Yoshiyuki,
Kishi Tomoya,
Ikeda Yuji,
Sakemi Takanobu,
Sanai Toru,
Node Koichi
Publication year - 2008
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2008.00596.x
Subject(s) - medicine , hypoproteinemia , nephrotic syndrome , focal segmental glomerulosclerosis , proteinuria , ldl apheresis , glomerulosclerosis , urology , hyperlipidemia , endocrinology , gastroenterology , cholesterol , lipoprotein , kidney , diabetes mellitus
We herein report the case of a 73‐year‐old woman with steroid and cyclosporine resistant collapsing focal segmental glomerulosclerosis (FSGS) whose refractory proteinuria and hypoproteinemia were controlled with low‐density lipoprotein apheresis (LDL‐A). She was initially treated with steroid therapy, including methylprednisolone pulse and cyclosporine therapy. However, her hypoproteinemia, accompanied with renal insufficiency, persisted despite these therapies. We treated her using LDL‐A and found improvement in her urine protein excretion, hyperlipidemia, hypoproteinemia, and renal function as a result of this treatment. This suggests that LDL‐A may therefore be an effective therapy for nephrotic syndrome due to collapsing FSGS.