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Effect of One‐year Oral α‐Tocopherol Administration on the Antioxidant Defense System in Hemodialysis Patients
Author(s) -
Antoniadi Georgia,
Eleftheriadis Theodoros,
Liakopoulos Vassilios,
Kakasi Eleni,
Kartsios Charalambos,
Passadakis Ploumis,
Vargemezis Vassilis
Publication year - 2008
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2008.00580.x
Subject(s) - medicine , antioxidant , glutathione peroxidase , vitamin e , oxidative stress , hemodialysis , placebo , oral administration , superoxide dismutase , pharmacology , vitamin c , population , alpha tocopherol , endocrinology , biochemistry , pathology , chemistry , alternative medicine , environmental health
Oxidative stress is increased in hemodialysis (HD) patients and contributes to the increased morbidity and mortality in this population. Vitamin E is an antioxidant agent. In the present study the effect of prolonged oral α‐tocopherol administration on the antioxidant defense system was evaluated. The antioxidant factors plasma total antioxidant status (TAS), red blood cell superoxide dismutase (SOD) activity and glutathione peroxidase (GPX) activity were evaluated with spectrometry in 27 HD patients. Measurements were performed before and after oral administration of α‐tocopherol at a dose of 500 mg/d for a one‐year period. Twenty HD patients received a placebo and 22 healthy volunteers served as controls. TAS was increased in HD patients. No difference was detected in SOD and GPX activity between HD patients and healthy volunteers. Tocopherol administration induced a significant decrease in TAS and SOD activity. Levels of GPX activity remained unaffected. All the evaluated factors remained stable in the HD patients receiving a placebo. Prolonged oral α‐tocopherol administration in HD patients induces a decrease in some components of the antioxidant defense system, raising the possibility for a pro‐oxidative role of vitamin E. Vitamin E is an antioxidant agent, but it is also known to have pro‐oxidant action under special conditions that can be encountered in HD patients.