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Hemoperfusion With an Immobilized Polymyxin B Fiber Column Reduces Circulating Interleukin‐8 Concentrations
Author(s) -
Kushi Hidehiko,
Miki Takahiro,
Nakahara Jun,
Okamoto Kazuhiko,
Kawahara Yayoi,
Saito Takeshi,
Tanjoh Katsuhisa
Publication year - 2006
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2006.00406.x
Subject(s) - hemoperfusion , medicine , polymyxin b , sepsis , sofa score , anesthesia , gastroenterology , hemodialysis , microbiology and biotechnology , antibiotics , biology
In the present study, we examined whether the performance of hemoperfusion with an immobilized polymyxin B fiber column (DHP‐PMX) reduces circulating interleukin‐8 concentration in patients with sepsis. Fifteen patients with sepsis satisfying the following criteria were enrolled in the study: (i) signs of systemic inflammatory response syndrome caused by infection; and (ii) mean arterial blood pressure ≥60 mm Hg (irrespective of the use of catecholamines). A thermodilution catheter was inserted prior to DHP‐PMX for appropriate intravenous infusion, and the DHP‐PMX was carried out twice at 24 h intervals (for 3 h each time). Circulating interleukin‐8 concentration was measured seven times. The sequential organ failure assessment (SOFA) score was calculated twice. Circulating interleukin‐8 concentration was 55 ± 15.7 pg/mL before DHP‐PMX, while it was 101 ± 58.8 pg/mL immediately after the first session of treatment. It was 24 ± 9.0 pg/mL before the second session of DHP‐PMX, and it was 28 ± 8.0 pg/mL immediately after the second session. The IL‐8 level was 17 ± 4.3 pg/mL at 48 h afterward, and 18 ± 4.3 pg/mL at 72 h afterward, showing a significant decrease from 48 h onwards, compared with before treatment ( P < 0.05). The SOFA score was 9 ± 1.5 and the APACHE II score was 19 ± 2.0 before DHP‐PMX, while the SOFA score was 7.0 ± 0.9 at 72 h afterward, showing a significant decrease compared with before treatment ( P < 0.05). The present findings indicate that DHP‐PMX indirectly reduces circulating interleukin‐8 concentration and improves SOFA score.