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Does a Reduction of Adhesion Molecules by LDL‐Apheresis Have a Role in the Treatment of Sudden Hearing Loss?
Author(s) -
Ramunni Alfonso,
Quaranta Nicola,
Saliani Maria Teresa,
Fallacara Rosa Anna,
Ria Roberto,
Ranieri Giuseppe
Publication year - 2006
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2006.00380.x
Subject(s) - medicine , apheresis , sudden hearing loss , reduction (mathematics) , hearing loss , intensive care medicine , audiology , platelet , geometry , mathematics
Sudden hearing loss (SHL) is a highly disabling affliction that can severely affect the subject’s social and relational life. Although the etiology of the complaint is still debated, it is thought that microcirculation disturbances conditioned by an endothelial dysfunction might be the main pathogenetic mechanism. Adhesion molecules favoring interaction between leukocytes and endothelial cells are early markers of endothelial damage. In the present report, we describe a case of SHL that derived evident benefit from a single session of LDL/fibrinogen apheresis, with complete hearing recovery. In this patient, in addition to reducing LDL cholesterol and fibrinogen, the circulating adhesion molecules (sE‐selectin, sVCAM‐1 and sICAM‐1), previously present in higher than normal concentrations, were reduced by the treatment.