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Recent Advances in Renal Phosphate Transport
Author(s) -
Hernando Nati,
Biber Jürg,
Forster Ian,
Murer Heini
Publication year - 2005
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2005.00290.x
Subject(s) - cotransporter , reabsorption , brush border , medicine , transporter , renal physiology , apical membrane , phosphate , homeostasis , microbiology and biotechnology , kidney , kidney tubules , endocrinology , membrane , biochemistry , pathology , sodium , epithelium , biology , gene , chemistry , vesicle , organic chemistry
Phosphate (P i ) homeostasis is achieved by adjusting the intestinal absorption and the renal excretion. Renal proximal reabsorption of P i is regulated by controlling the amount of NaPi‐IIa cotransporters in the brush border membrane of proximal tubules. Therefore, the understanding of the molecular mechanisms that control the apical expression of NaPi‐IIa is required to have a full picture of how phosphate balancing takes place. In this review we will summarize our present knowledge about the mechanisms involved in the regulation of the apical expression and membrane retrieval of this family of transporters.