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Treatment of Pyoderma Gangrenosum With Granulocyte and Monocyte Adsorption Apheresis
Author(s) -
Kanekura Takuro,
Kawahara Koichi,
Maruyama Ikuro,
Kanzaki Tamotsu
Publication year - 2005
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1744-9987.2005.00284.x
Subject(s) - pyoderma gangrenosum , medicine , apheresis , groin , granulocyte , dermatology , surgery , pathology , platelet , disease
Pyoderma gangrenosum is an intractable skin disorder characterized by the development of erythematous pustules or nodules that rapidly progress to destructive, necrotizing, non‐infective ulcers. We assessed the efficacy of granulocyte and monocyte adsorption apheresis (GCAP) therapy in two new patients, a 67‐year‐old man with ulcerations on his lower leg, and a 44‐year‐old man with turgid erythematous lesions with burrowing abscesses and sinus formation on his hip, groin, and thighs. Both patients received 10 GCAP treatments at 5‐day intervals. Their skin lesions responded well. The 9 cm × 6 cm ulcer on the lower right leg of the 67‐year‐old patient was completely covered by regenerated skin at the completion of therapy. The turgid skin lesions containing pustules and ulcers of the other patient showed amelioration and a marked decrease in the volume of exudate. Our results suggest that GCAP is a useful treatment modality for pyoderma gangrenosum.