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Effects of cyhalothrin on the transient outward potassium current in central neurons of Helicoverpa armigera
Author(s) -
WANG YONG,
HE BINGJUN,
ZHAO QIANG,
LIANG ZHI,
LIU ANXI
Publication year - 2006
Publication title -
insect science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 45
eISSN - 1744-7917
pISSN - 1672-9609
DOI - 10.1111/j.1744-7917.2006.00062.x
Subject(s) - cyhalothrin , helicoverpa armigera , neurotoxicity , potassium , biology , biophysics , toxicology , patch clamp , anatomy , medicine , chemistry , pesticide , neuroscience , electrophysiology , botany , toxicity , larva , ecology , organic chemistry
The effects of cyhalothrin on the transient outward potassium current in central neurons of Helicoverpa armigera were studied by using the patch clamp techniques. The results showed that before using cyhalothrin (10 −5 mmol/L), activation potential was approximately ‐40 mV, after application of the drug, the activation potential shifted roughly 10 mV to the negative potential direction, so channels can be activated more easily. Before and after cyhalothrin application, the change of current amplitude was insignificant. The value of V 1/2 and k of activation curves did not change significantly, however, the V 1/2 of the inactivation curves changed significantly. Inactivation curves significantly shifted to a negative direction, so that inactivation of the channels was hastened. It is indicated that there may exit a primary way in which cyhalothrin provides neurotoxicity to the nervous system through the regulation of activation potentials and inactivation state of I A channels.