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PRELIMINARY OBSERVATION OF TOXICOLOGICAL EFFECTS OF RHODOJAPONINS AND TOOSENDANIN ON NEUROMUSCULAR TRANSMISSION OF LARVAL DROSOPHILA MELANGASTER MEIGEN
Author(s) -
Xu Jianhua,
Liu Anxi,
Shang Zhizhen
Publication year - 1996
Publication title -
insect science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 45
eISSN - 1744-7917
pISSN - 1672-9609
DOI - 10.1111/j.1744-7917.1996.tb00283.x
Subject(s) - biology , neuromuscular transmission , neuromuscular junction , larva , drosophila (subgenus) , inhibitory postsynaptic potential , excitatory postsynaptic potential , toxicology , botany , biochemistry , gene , neuroscience , endocrinology
With microeletrode intracellular recording technique, the three rhodojaponins and toosendanin, which had been extracted and purified from two insecticidal plants, Rhododendron molle and Melia toosendan , respectively, were examined for their toxicological effects on the neuromuscular excitatory junction potentials (EJPS) in the ventralateral longitudinal muscle cells of the third instar larval Drosophila melangaster Meigen. All of them were found to inhibit and eventually block the EJPS, and the time for blockage decreased with higher concentrations. Comparison among the three rhodojaponins showed an inhibitory activity sequence of rhdojaponin I >rhodojaponin I >rhodojaponin V. This preliminary observation suggested that the disruption of neuromuscular transmission might contribute to the fatal actions of these botanic insecticides.