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A Cytotoxic Neolignan from Schisandra propinqua (Wall.) Baill.
Author(s) -
Xu LiJia,
Huang Feng,
Chen SiBao,
Li LianNiang,
Chen ShiLin,
Xiao PeiGen
Publication year - 2006
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/j.1744-7909.2006.00323.x
Subject(s) - schisandra chinensis , cytotoxicity , stereochemistry , chemistry , bromide , bioassay , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , traditional medicine , organic chemistry , in vitro , biology , biochemistry , medicine , alternative medicine , pathology , traditional chinese medicine , genetics
Abstract In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua (Wall.) Baill. The structure of the new compound was determined to be 4, 4‐di (4‐hydroxy‐3‐methoxyphenly)‐2, 3‐dimethylbutanol (compound 1) on the basis of 1 H‐ and 13 C‐NMR spectra and 2D NMR methods. Eight known compounds, compounds 2‐9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1‐4 were evaluated for cytotoxicity by an 3‐(4,5‐dimethyl‐2 thiazoyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay. Compound 1 showed significant potential cytotoxic ability in the bioassay. (Managing editor: Wei Wang)