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Two New Cytotoxic Sesquiterpenoids from Eupatorium lindleyanum DC.
Author(s) -
Huo Jun,
Yang ShengPing,
Ding Jian,
Yue JianMin
Publication year - 2006
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/j.1744-7909.2006.00226.x
Subject(s) - eupatorium , cytotoxic t cell , cytotoxicity , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , chemistry , spectral analysis , biology , botany , biochemistry , physics , spectroscopy , in vitro , quantum mechanics
Two new sesquiterpenoid lactones, namely eupalinilides K and L, were isolated from Eupatorium lindleyanum DC. Their structures were determined by spectral methods, including 1D‐ and 2D‐NMR spectra. Cytotoxic evaluation showed that eupalinilide L exhibited potent cytotoxicity against P‐388 and A‐549 tumor cell lines with IC 50 values of 0.17 and 2.60 μmol/L, respectively. (Managing editor: Wei Wang).
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